Tissue dynamics and regenerative outcome in two resorbable non-chemically cross-linked collagen membranes for guided bone regeneration: A preclinical molecular and histological study in vivo.
The potential for some membranes used in guided bone regeneration (GBR) to behave as bioactive modulators of bone healing is increasingly being recognized.
This study1 used a rodent model to investigate how two non-cross-linked collagen membranes, creos xenoprotect and Bio-Gide®, promoted cellular and molecular activity during bone healing in GBR. After the introduction of defects in the femoral epi-physis (trabecular bone) of anaesthetized rats, investigational sites were filled with deproteinized bovine bone and covered with either creos xenoprotect or Bio-Gide®.
Both membranes promoted a comparable amount of bone formation overall. However, only creos xenoprotect encouraged significant new bone formation in the central region of the defects. These results suggest that creos xenoprotect, rather than being a mere passive barrier, may play an active role in regulating bone healing dynamics as well.
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Omar et al., Clin Oral Implants Res. 2017; doi: 10.1111/clr.13032